Tripterygium Wilfordii Thunder God Vine

Thunder God Vine / Tripterygium Wilfordii

History

Tripterygium wilfordii / Thunder God Vine also known as:

Léi gōng téng
Thunder duke vine

is regarded as a promising traditional medicinal plant showing several, mainly antiinflammatory and cytotoxic activities. It contains unusual natural compounds currently being researched . The species has been well known in Traditional Chinese Medicine but was recognized in Western science as an insecticide not before the 1930’s and as a promising medicinal plant in the 1960’s. The name refers to Charles Wilford, employed as a botanical collector at Kew Botanical Gardens, London from 1857–1860. He collected the plant on the island of Taiwan, formerly called Formosa, in June 1858, Charles wilford discovered the primary plant in Korea and Vietnam. without reporting its medicinal use in the country of origin. The plant was named according to the Linnaean system before 1862 what initially concealed its medicinal properties which had to be re-discovered in the second half of the 20th century.

In the latter half of the twentieth century, interest again returned. presently more money has been spent researching tripterygium than any other botanical in regard to almost all disease this includes the many compounds within tripterygium, some of which are listed below. There are research articles that classify tripterygium as an immune modulator or even a limiter. I urge scientist to do deeper research into this, simply because the vast amount of data may be in conflict with this conclusion and therefore the herb may be affecting a bacteria upstream from the current standard of measurement.

I am very concerned that research dollars are being spent to learn how to disable key herbal compounds such as tripolide within tripterygium this information can be used to create this gene mutation through any vaccination program or genetically modified food source.

Mutation of Cys342 of XPB to threonine conferred resistance to triptolide on the mutant protein. Replacement of the endogenous wild‐type XPB with the Cys342Thr mutant in a HEK293T cell line rendered it completely resistant to triptolide,

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201408817

The FDA approved cancer drug "Taxol" that was based on a tree bark related to tripterygium wilfordii / Thunder god vine was native and harvested in Afghanistan. The road leading to this treasure trove of trees has since been left inaccessible post Afghan war. This all occurred as the patent for this breakthrough FDA approved application of this tripterygium expired.

The most studied compounds within Thunder God Vine are:
Triptolide
Celastrol
Demethylzeylastera
Tripchloroide

Mutation of Cys342 of XPB to threonine conferred resistance to triptolide on the mutant protein. Replacement of the endogenous wild‐type XPB with the Cys342Thr mutant in a HEK293T cell line rendered it completely resistant to triptolide,

https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201408817

Research articles