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AIDS Human study 

“Use of Tripterygium wilfordii Hook F extract (TwHF) extract in HIV-infected patients was associated with a reduction in T-cell activation and improved CD4 recovery with an excellent safety profile.”
Tripterygium wilfordii Hook F extract in cART-treated HIV patients with poor immune response: a pilot study to assess its immunomodulatory effects and safety

​Despite combination antiretroviral therapy (cART), 20% of HIV-infected patients are unable to achieve adequate immunologic recovery, in which immune activation plays a crucial role. We hypothesize that extract of Tripterygium wilfordii Hook F (TwHF), a Chinese medication used to treat autoimmune diseases, has immunomodulatory effects that may help CD4 cell recovery. Eighteen cART-treated HIV-infected patients virally suppressed for over 12 months with suboptimal CD4 cell recovery were enrolled. TwHF extract was administered at a dosage of 10 mg three times daily for 12 months. T-cell subsets and activation markers were evaluated at baseline and during follow-up. The trial was registered at Clinicaltrials.gov (NCT02002286). TwHF extract was associated with a mean increase in CD4 cell count of 88 cells/μl (95% confidential interval [CI], 72-105 cells/μl) after one year of treatment. A significant increase in the mean rate of CD4 cell recovery (26 before vs 75 cells/μl/year after TwHF use, P < 0.001) was observed. Analysis of 13 patients with activation profiles suggested that TwHF extract was associated with a decrease in T-cell immune activation which was temporally correlated with CD4 cell recovery. No discontinuation of TwHF extract was reported. Use of TwHF extract in HIV-infected patients was associated with a reduction in T-cell activation and improved CD4 recovery with an excellent safety profile.

https://www.researchgate.net/publication/273387703_Tripterygium_wilfordii_Hook_F_extract_in_cART-treated_HIV_patients_with_poor_immune_response_a_pilot_study_to_assess_its_immunomodulatory_effects_and_safety


Timothy Telymonde
​253 Main Street

Suite 355
Matawan, NJ 07747
+1-(740) 352-9594
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*Disclaimer: 
All information discussed/printed herein and/or by our business affiliates do not constitute medical advice. We recommend that you consult your physician and/or health care professionals to determine if this product or products are right for you before consumption, especially if you are taking medications for any medical conditions, and to avoid any possible side effects. These statements have not been evaluated by the Food and Drug Administration. Further, this product is not intended to diagnose, treat, cure or prevent any disease. Expressly, all information supplied within our website or related public domains or during verbal discussion with any owner, owners, affiliates, or users’ testimonials have no warranty whatsoever. Since our product has not been tested in peer-reviewed double-blind controlled studies, all testimonials associated with this product should not provide assurance that you will have a similar outcome and/or similar side effects. You should clearly understand the above statements and fully accept total responsibility for what you do with the information and the resulting outcomes from your actions.  

If you are pregnant, lactating or are planning a pregnancy do not use this product. While on this product you may temporarily have a lower sperm count. Do not use if seal is broken. Keep out of reach of children, For adults only . store in a cool dry place.


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  • Home
    • Flawless Defense Plus
  • Tripterygium Wilfordii Thunder God Vine
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