A study of tripterygium wilfordii Hook F Treatment for Idiopathic Refractory Nephrotic Syndrome in Adults

Nephrotic syndrome is a collection of symptoms due to kidney damage.[1] This includes protein in the urine, low blood albumin levels, high blood lipids, and significant swelling.[1] Other symptoms may include weight gain, feeling tired, and foamy urine.[1] Complications may include blood clots, infections, and high blood pressure.[1] .  https://en.wikipedia.org/wiki/Nephrotic_syndrome

Tripterygium wilfordii Hook F Treatment for Idiopathic Refractory Nephrotic Syndrome in Adults: A Meta-AnalysisXu G.a, b · Tu W.a · Jiang D.b · Xu C.a
 Author affiliations
Keywords: Nephrotic syndromeRefractory nephrotic syndromeIdiopathic refractory nephrotic syndrome, meta-analysisImmunosuppressive agentsTripterygium wilfordii Hook F

Nephron Clin Pract 2009;111:c223
https://doi.org/10.1159/000208990 AbstractTripterygium wilfordii Hook F (TwHF) is a Chinese herbal medicine with immunosuppressive effects and an established history of use in the treatment of inflammatory and autoimmune diseases. We have carried out a meta-analysis of randomized controlled trials (RCTs) and quasi-RCTs which assessed the effectiveness of TwHF in the treatment for idiopathic refractory nephrotic syndrome (IRNS). After reading the full text, only three RCTs or quasi-RCTs meeting our inclusion criteria were selected. Our meta-analysis indicated that TwHF has beneficial effects on the remission of IRNS. There was no significant publication bias in the meta-analysis studies. However, studies with a larger sample size and including patients with both a mild and severe histopathological change involvement separately are needed to assess the effects of TwHF in IRNS patients before exact conclusions can be drawn.
© 2009 S. Karger AG, Basel8-[

click on this link for the full abstract https://www.karger.com/Article/Abstract/208990
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