Thunder God Vine / Tripterygium Wilfordii
Ask yourself how the many studies and informational links regarding this single herb, may impact your personal health and wellness
History
Tripterygium wilfordii / Thunder God Vine also known as:
In the latter half of the twentieth century, interest again returned. presently more money has been spent researching tripterygium than any other botanical in regard to almost all disease this includes the many compounds within tripterygium, some of which are listed below. There are research articles that classify tripterygium as an immune modulator or even a limiter. I urge scientist to do deeper research into this, simply because the vast amount of data may be in conflict with this conclusion and therefore the herb may be affecting a bacteria upstream from the current standard of measurement.
I am very concerned that research dollars are being spent to learn how to disable key herbal compounds such as tripolide within tripterygium this information can be used to create this gene mutation through any vaccination program or genetically modified food source.
Mutation of Cys342 of XPB to threonine conferred resistance to triptolide on the mutant protein. Replacement of the endogenous wild‐type XPB with the Cys342Thr mutant in a HEK293T cell line rendered it completely resistant to triptolide,
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201408817
The FDA approved cancer drug "Taxol" that was based on a tree bark related to tripterygium wilfordii / Thunder god vine was native and harvested in Afghanistan. The road leading to this treasure trove of trees has since been left inaccessible post Afghan war. This all occurred as the patent for this breakthrough FDA approved application of this tripterygium expired.
The most studied compounds within Thunder God Vine are:
Triptolide
Celastrol
Demethylzeylastera
Tripchloroide
Mutation of Cys342 of XPB to threonine conferred resistance to triptolide on the mutant protein. Replacement of the endogenous wild‐type XPB with the Cys342Thr mutant in a HEK293T cell line rendered it completely resistant to triptolide,
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201408817
- Léi gōng téng
- Thunder duke vine
In the latter half of the twentieth century, interest again returned. presently more money has been spent researching tripterygium than any other botanical in regard to almost all disease this includes the many compounds within tripterygium, some of which are listed below. There are research articles that classify tripterygium as an immune modulator or even a limiter. I urge scientist to do deeper research into this, simply because the vast amount of data may be in conflict with this conclusion and therefore the herb may be affecting a bacteria upstream from the current standard of measurement.
I am very concerned that research dollars are being spent to learn how to disable key herbal compounds such as tripolide within tripterygium this information can be used to create this gene mutation through any vaccination program or genetically modified food source.
Mutation of Cys342 of XPB to threonine conferred resistance to triptolide on the mutant protein. Replacement of the endogenous wild‐type XPB with the Cys342Thr mutant in a HEK293T cell line rendered it completely resistant to triptolide,
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201408817
The FDA approved cancer drug "Taxol" that was based on a tree bark related to tripterygium wilfordii / Thunder god vine was native and harvested in Afghanistan. The road leading to this treasure trove of trees has since been left inaccessible post Afghan war. This all occurred as the patent for this breakthrough FDA approved application of this tripterygium expired.
The most studied compounds within Thunder God Vine are:
Triptolide
Celastrol
Demethylzeylastera
Tripchloroide
Mutation of Cys342 of XPB to threonine conferred resistance to triptolide on the mutant protein. Replacement of the endogenous wild‐type XPB with the Cys342Thr mutant in a HEK293T cell line rendered it completely resistant to triptolide,
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201408817
Research articles
VERYWELLHELATH.COM DID A NICE JOB ON THIS PIECE WHICH INCLUDES A PLETHORA OF SUPPORTING LINKS.
https://www.verywellhealth.com/health-benefits-of-thunder-god-vine-89081
Nutritional support of Joint pain in a double blind placebo based study
https://pubmed.ncbi.nlm.nih.gov/2509153/
https://pubmed.ncbi.nlm.nih.gov/12124856/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938780/
Nutritional support of lower spine inflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908750/
https://pubmed.ncbi.nlm.nih.gov/25760304/
https://pubmed.ncbi.nlm.nih.gov/26255190/
Kidney Disease
https://pubmed.ncbi.nlm.nih.gov/26909960/
https://selfhacked.com/blog/15-promising-thunder-god-vine-benefits/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434037/
Diabetic neuropathy kidney related disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670993/
Nutritional support of Psoriasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937555/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477344/
Nutritional support of skin lesions
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990293/
Nutritional support of Allergies
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119305/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044903/
Nutritional support of Crohns disease
https://pubmed.ncbi.nlm.nih.gov/17410440/
https://pubmed.ncbi.nlm.nih.gov/23569144/
https://pubmed.ncbi.nlm.nih.gov/26473333/
https://pubmed.ncbi.nlm.nih.gov/19296254/
https://pubmed.ncbi.nlm.nih.gov/25445405/
human cell potential nutritional benefits
https://pubmed.ncbi.nlm.nih.gov/20615550/
Research regarding oral Herpes viruses
https://pubmed.ncbi.nlm.nih.gov/8722541/
Research regarding Herpes 2 viruses
https://pubmed.ncbi.nlm.nih.gov/22148431/
Research regarding AIDS
HTTPS://PUBMED.NCBI.NLM.NIH.GOV/8722541/
https://pubmed.ncbi.nlm.nih.gov/1375626/
https://pubmed.ncbi.nlm.nih.gov/8564400/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205289/
https://pubmed.ncbi.nlm.nih.gov/10757718/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140654/
Research on Hepatitis C
https://pubmed.ncbi.nlm.nih.gov/28935193/
https://pubmed.ncbi.nlm.nih.gov/29435894/
Research on dengue
https://pubmed.ncbi.nlm.nih.gov/27847245/
Research on HSV-1, Human cytomegalovirus, measles virus and influenza A virus
https://pubmed.ncbi.nlm.nih.gov/8722541/
Research on lupus
https://pubmed.ncbi.nlm.nih.gov/2791160/
https://pubmed.ncbi.nlm.nih.gov/18652362/
https://pubmed.ncbi.nlm.nih.gov/25058036/
https://pubmed.ncbi.nlm.nih.gov/1445458/
http://pubmed.ncbi.nlm.nih.gov/1728981/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1754486/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526566/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560846/
https://pubmed.ncbi.nlm.nih.gov/15840409/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514757/
Research on Multiple Sclerosis
https://pubmed.ncbi.nlm.nih.gov/28983582/
https://pubmed.ncbi.nlm.nih.gov/25662403/
https://pubmed.ncbi.nlm.nih.gov/25218987/
https://pubmed.ncbi.nlm.nih.gov/19796825/
https://pubmed.ncbi.nlm.nih.gov/18438925/
The following is the fourth paragraph of a very interesting cancer research article completed by johns hopkins
Triptolide, the active ingredient purified from the plant Tripterygium wilfordii Hook F, has been shown in animal models to be effective against cancer, arthritis and skin graft rejection. In fact, says Liu, triptolide has been shown to block the growth of all 60 U.S. National Cancer Institute cell lines at very low doses, and even causes some of those cell lines to die. Other experiments have suggested that triptolide interferes with proteins known to activate genes, which gives Liu and colleagues an entry point into their research.
Here in the link to the full article
https://www.hopkinsmedicine.org/news/media/releases/solving_a_traditional_chinese_medicine_mystery
Additional Research on cancer:
Liver
https://pubmed.ncbi.nlm.nih.gov/27181068/
https://pubmed.ncbi.nlm.nih.gov/9259407/
https://pubmed.ncbi.nlm.nih.gov/24859482/
https://pubmed.ncbi.nlm.nih.gov/23715750/
https://pubmed.ncbi.nlm.nih.gov/25661995/
Bile duct
https://pubmed.ncbi.nlm.nih.gov/10072166/
https://pubmed.ncbi.nlm.nih.gov/12587840/
https://pubmed.ncbi.nlm.nih.gov/16475706/
Research on Lung
https://pubmed.ncbi.nlm.nih.gov/20472666/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630145/
https://pubmed.ncbi.nlm.nih.gov/29864943/
https://pubmed.ncbi.nlm.nih.gov/21466843/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104056/
https://pubmed.ncbi.nlm.nih.gov/29428961/
https://pubmed.ncbi.nlm.nih.gov/17110449/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271537/
https://pubmed.ncbi.nlm.nih.gov/12934102/
https://pubmed.ncbi.nlm.nih.gov/27498688/
https://pubmed.ncbi.nlm.nih.gov/12526088/
Research on Breast cancer
https://pubmed.ncbi.nlm.nih.gov/12533674/
https://pubmed.ncbi.nlm.nih.gov/30729271/
https://pubmed.ncbi.nlm.nih.gov/29614269/
https://pubmed.ncbi.nlm.nih.gov/9029176/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422943/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294079/
https://pubmed.ncbi.nlm.nih.gov/1819894/
https://pubmed.ncbi.nlm.nih.gov/21805042/
https://pubmed.ncbi.nlm.nih.gov/18572307/
https://pubmed.ncbi.nlm.nih.gov/19524422/
https://pubmed.ncbi.nlm.nih.gov/23467622/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079444/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772696/
https://pubmed.ncbi.nlm.nih.gov/30551406/
https://pubmed.ncbi.nlm.nih.gov/29500880/
Research on Ovarian Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509180/
https://pubmed.ncbi.nlm.nih.gov/18073474/
https://pubmed.ncbi.nlm.nih.gov/26786618/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958983/
https://pubmed.ncbi.nlm.nih.gov/20547442/
https://pubmed.ncbi.nlm.nih.gov/18073474/
Research on Prostate Cancer
https://pubmed.ncbi.nlm.nih.gov/16651429/
https://pubmed.ncbi.nlm.nih.gov/28195223/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868692/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364364/
https://pubmed.ncbi.nlm.nih.gov/12171899/
https://pubmed.ncbi.nlm.nih.gov/27847199/
https://pubmed.ncbi.nlm.nih.gov/28349980/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636169/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479278/
https://pubmed.ncbi.nlm.nih.gov/27501757/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230278/
https://pubmed.ncbi.nlm.nih.gov/23906293/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308648/
Research on Bladder Cancer
https://pubmed.ncbi.nlm.nih.gov/12533674/
https://pubmed.ncbi.nlm.nih.gov/17110449/
Research on Stomach Cancer
https://pubmed.ncbi.nlm.nih.gov/12533674/
https://pubmed.ncbi.nlm.nih.gov/1819894/
https://pubmed.ncbi.nlm.nih.gov/11753684/
https://pubmed.ncbi.nlm.nih.gov/17970088/
https://pubmed.ncbi.nlm.nih.gov/22306340/
Research on Colon Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772974/
https://pubmed.ncbi.nlm.nih.gov/22315045/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001951/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600066/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600066/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728221/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711309/
https://pubmed.ncbi.nlm.nih.gov/21640813/
https://pubmed.ncbi.nlm.nih.gov/22464014/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949684/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331187/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940375/
Research on upper Throat Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940375/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312946/
Research on Brain Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312946/
https://pubmed.ncbi.nlm.nih.gov/19719969/
https://pubmed.ncbi.nlm.nih.gov/17697526/
https://pubmed.ncbi.nlm.nih.gov/30156009/
https://pubmed.ncbi.nlm.nih.gov/17900403/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180101/
Research on Pituitary Gland Cancer
https://pubmed.ncbi.nlm.nih.gov/28892788/
https://pubmed.ncbi.nlm.nih.gov/29288766/
Research on Lymph node Cancer
https://pubmed.ncbi.nlm.nih.gov/29288766/
https://pubmed.ncbi.nlm.nih.gov/28666825/
https://pubmed.ncbi.nlm.nih.gov/29901111/
https://pubmed.ncbi.nlm.nih.gov/26631963/
https://pubmed.ncbi.nlm.nih.gov/21640813/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649517/
https://pubmed.ncbi.nlm.nih.gov/17049119/
Research on Leukemia Cancer
https://pubmed.ncbi.nlm.nih.gov/17049119/
https://pubmed.ncbi.nlm.nih.gov/26990902/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877542/
https://pubmed.ncbi.nlm.nih.gov/15101726/
https://pubmed.ncbi.nlm.nih.gov/20346213/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895484/
https://pubmed.ncbi.nlm.nih.gov/20691473/
https://pubmed.ncbi.nlm.nih.gov/16316721/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570632/
https://pubmed.ncbi.nlm.nih.gov/15663903/
https://pubmed.ncbi.nlm.nih.gov/27908660/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274014/
Research on White Blood Cell (multiple myeloma) Cancer
https://pubmed.ncbi.nlm.nih.gov/28338993/
https://pubmed.ncbi.nlm.nih.gov/26420049/
https://pubmed.ncbi.nlm.nih.gov/21850367/
https://pubmed.ncbi.nlm.nih.gov/24481531/
https://pubmed.ncbi.nlm.nih.gov/20547150/
https://pubmed.ncbi.nlm.nih.gov/18813856/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995890/
https://pubmed.ncbi.nlm.nih.gov/19879315/
https://pubmed.ncbi.nlm.nih.gov/17110449/
Research on skin cancer
https://pubmed.ncbi.nlm.nih.gov/20472666/
https://pubmed.ncbi.nlm.nih.gov/12533674/
https://pubmed.ncbi.nlm.nih.gov/23975869/
https://pubmed.ncbi.nlm.nih.gov/23975869/
https://pubmed.ncbi.nlm.nih.gov/26420756/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682691/
Compounds within Tripterygium wilfordii were active against the following cancer types in cell-based studies only:
Soft tissue and bone (sarcoma)
https://pubmed.ncbi.nlm.nih.gov/16176806/
https://pubmed.ncbi.nlm.nih.gov/29330051/
https://pubmed.ncbi.nlm.nih.gov/21771704/
https://pubmed.ncbi.nlm.nih.gov/28522217/
https://pubmed.ncbi.nlm.nih.gov/27461934/
https://pubmed.ncbi.nlm.nih.gov/24772972/
Uterus
https://pubmed.ncbi.nlm.nih.gov/24772972/
https://pubmed.ncbi.nlm.nih.gov/24213358/
https://pubmed.ncbi.nlm.nih.gov/20547442/
Research on Cervical cancer
https://pubmed.ncbi.nlm.nih.gov/16385419/
https://pubmed.ncbi.nlm.nih.gov/20878065/
https://pubmed.ncbi.nlm.nih.gov/27819370/
https://pubmed.ncbi.nlm.nih.gov/16176806/
Research on Pancreatic Cancer
https://pubmed.ncbi.nlm.nih.gov/16385419/
https://pubmed.ncbi.nlm.nih.gov/29238973/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693742/
https://pubmed.ncbi.nlm.nih.gov/29238973/
https://pubmed.ncbi.nlm.nih.gov/21213403/
Research on Adrenal gland cancer
https://pubmed.ncbi.nlm.nih.gov/21152873/
Research on the nervous system
Alzheimers
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257007/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090855/
https://pubmed.ncbi.nlm.nih.gov/26906357/
https://pubmed.ncbi.nlm.nih.gov/23715750/
https://pubmed.ncbi.nlm.nih.gov/25661995/
Stroke
https://pubmed.ncbi.nlm.nih.gov/26575184/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888863/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406066/
Spinal cord injury
https://pubmed.ncbi.nlm.nih.gov/20155820/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417433/
Traumatic brain injury
https://pubmed.ncbi.nlm.nih.gov/22366865/
Aging
https://pubmed.ncbi.nlm.nih.gov/24140565/
Toxins
https://pubmed.ncbi.nlm.nih.gov/12504865/
The following compounds within Tripterygium wilfordii may provide nutritional support to Alzheimers and Parkinsons. see the links below for more information.
https://pubmed.ncbi.nlm.nih.gov/26679104/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640509/
https://pubmed.ncbi.nlm.nih.gov/22986777/
https://pubmed.ncbi.nlm.nih.gov/19170180/
https://pubmed.ncbi.nlm.nih.gov/22498763/
https://pubmed.ncbi.nlm.nih.gov/23619395/
https://pubmed.ncbi.nlm.nih.gov/12504865/
https://pubmed.ncbi.nlm.nih.gov/20626064/
https://pubmed.ncbi.nlm.nih.gov/18602088/
May provide nutritional Heart support for
Chronic heart failure
https://pubmed.ncbi.nlm.nih.gov/26012254/
Diabeties related heart disease.
https://pubmed.ncbi.nlm.nih.gov/27558948/
Hi Blood pressure
https://pubmed.ncbi.nlm.nih.gov/28202417/
https://pubmed.ncbi.nlm.nih.gov/26391895/pubmed.ncbi.nlm.nih.gov/26391895/
https://pubmed.ncbi.nlm.nih.gov/26391895/pubmed.ncbi.nlm.nih.gov/26391895/
Possibly nutritionally support the return of blood flow after heart attacks (ischemia-reperfusion injury)
https://pubmed.ncbi.nlm.nih.gov/26391895/
Obesity Nutritional Support:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768733/
https://pubmed.ncbi.nlm.nih.gov/26344102/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761061/
https://pubmed.ncbi.nlm.nih.gov/30742994/
https://pubmed.ncbi.nlm.nih.gov/30706713/
https://pubmed.ncbi.nlm.nih.gov/30414673/
https://pubmed.ncbi.nlm.nih.gov/27085773/
Nutritional support of Obesity in diabetic Rats
https://pubmed.ncbi.nlm.nih.gov/20483955/
Thunder god vine may nutritionally reduce inflammation in rats infected with a bacterium (Ureaplasma urealyticum) that causes prostate inflammation or prostatitis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070633/
Celastrol a compound found within tripterygium wilfordii may provide nutritional support of enlarged prostate.
https://pubmed.ncbi.nlm.nih.gov/26073338/
https://pubmed.ncbi.nlm.nih.gov/28558869/
Nutritional support of Eye Health
Triptolide a compound found in tripterygium wilfordii may support the reduction of inflammation within the cornea
https://pubmed.ncbi.nlm.nih.gov/15980221/
https://pubmed.ncbi.nlm.nih.gov/28233432/
Celastrol a compound found in tripterygium may nutritionally support the healing and repair of nerves damaged under pressure such as with glaucoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417422/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959052/
Promising new drugs may be on the horizon utilizing compounds found within Thunder God Vine / Tripterygium, that may improve both vascular disease and cancerous tumors.
Here is the link to the full article:
https://pubmed.ncbi.nlm.nih.gov/9259407/
This is an interesting link regarding a study showing tripterygium not to be inferior to methotrexate regarding nutritional support joint pain
Here is the link to the abstract.
https://pubmed.ncbi.nlm.nih.gov/21085018/
A paper on spinal pain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908750/
A potential breakthrough paper on proteinuria related kidney disease.
https://pubmed.ncbi.nlm.nih.gov/29193402/
A paper in airway inflammation.
https://pubmed.ncbi.nlm.nih.gov/23321997/
A common Intestinal disease research article
https://pubmed.ncbi.nlm.nih.gov/26473333/
Anti-transplant articles exist regarding the Kidneys, Heart, Liver, Bone marrow, Small bowel, Pancreatic tissue, Corona, Nerves and Skin.
Kidneys
https://pubmed.ncbi.nlm.nih.gov/10949186/
Heart
https;//pubmed.ncbi.nlm.nih.gov/10455961/
Bone marrow
https://pubmed.ncbi.nlm.nih.gov/10627483/
Liver
htps;//pubmed.ncbi.nlm.nih.gov/11120063/
Small bowel
https://pubmed.ncbi.nlm.nih.gov/7774436/
Corona
https://pubmed.ncbi.nlm.nih.gov/8758847/
Nerves
https://pubmed.ncbi.nlm.nih.gov/19192890/
Skin
https://pubmed.ncbi.nlm.nih.gov/16529697/
I question this engineered folding mutation that makes triptolide ineffective.
Triptolide blocks most of these pathways by binding to the TFIIH protein. A mutation (Cys342Thr) prevents interaction with triptolide
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622543/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314353/
I am bothered by the fact that the mutation that blocks the function of triptolide is a protein folding mutation in which the public was asked to participate in. further this mutation is patented.
The following was marketed as a game however the research results can be use to make natural super herbs ineffective which is very serious in my opinion.
https://en.wikipedia.org/wiki/Foldit