FLAWLESS HERBS
  • Home
  • Flawless Defense Plus
  • Tripterygium Wilfordii Thunder God Vine
  • contact us
  • side effects
  • Testing
  • Affiliated sites
  • Tree of life

Human Tripterygium rheumatoid arthritis study

Ann Rheum Dis. 2015 Jun;74(6):1078-86. doi: 10.1136/annrheumdis-2013-204807. Epub 2014 Apr 14.Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial.Lv QW1, Zhang W1, Shi Q1, Zheng WJ1, Li X1, Chen H1, Wu QJ1, Jiang WL1, Li HB2, Gong L3, Wei W3, Liu H4, Liu AJ5, Jin HT5, Wang JX6, Liu XM7, Li ZB8, Liu B9, Shen M1, Wang Q1, Wu XN1, Liang D1, Yin YF1, Fei YY1, Su JM1, Zhao LD1, Jiang Y1, Li J1, Tang FL1, Zhang FC1, Lipsky PE10, Zhang X1.Author information1
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
2
Department of Rheumatology, Affiliated Hospital of Inner Mongolia Medical College, Huhhot, China.
3
Department of Rheumatology, General Hospital of Tianjin Medical University, Tianjin, China.
4
Department of Rheumatology, Beijing Dongfang Hospital, Beijing, China.
5
Department of Rheumatology, Second Hospital of Hebei Medical University, Hebei, China.
6
Department of Rheumatology, Third Hospital of Hebei Medical University, Hebei, China.
7
Department of Rheumatology, First Hospital of Shanxi Medical University, Shanxi, China.
8
Department of Rheumatology, The Bethune International Heping Hospital of Hebei, Hebei, China.
9
Department of Rheumatology, The Affiliated Hospital of QingDao University Medical College, Shandong, China.
10
Formerly National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.AbstractOBJECTIVES:To compare the efficacy and safety of Tripterygium wilfordii Hook F (TwHF) with methotrexate (MTX) in the treatment of active rheumatoid arthritis (RA).
METHODS:Design: a multicentre, open-label, randomised controlled trial. All patients were assessed by trained investigators who were unaware of the therapeutic regimen.
INTERVENTION:207 patients with active RA were randomly allocated (1:1:1) to treatment with MTX 12.5 mg once a week, or TwHF 20 mg three times a day, or the two in combination. At week 12, if reduction of the 28-joint count Disease Activity Score (DAS28) was <30% in the monotherapy groups, the patient was switched to MTX+TwHF. The primary efficacy point was the proportion of patients achieving an American College of Rheumatology (ACR) 50 response at week 24.
RESULTS:174/207 (84.1%) patients completed 24 weeks of the trial. In an intention-to-treat analysis, the proportion of patients reaching the ACR50 response criteria was 46.4% (32/69), 55.1% (38/69) and 76.8% (53/69), respectively, in the MTX, TwHF and MTX+TwHF groups (TwHF vs MTX monotherapy, p=0.014; MTX+TwHF vs MTX monotherapy, p<0.001). Similar statistically significant patterns at week 24 were found for ACR20, ACR70, clinical Disease Activity Index good responses, EULAR good response, remission rate and low disease activity rate. Significant improvement in the Health Assessment Questionnaire and 36-item Short-Form Health Survey questionnaire scores from baseline to week 24 was seen in each treatment arm (p<0.05), though no significant difference was found among the treatment arms (p>0.05). The result of per-protocol analysis agreed with that seen in the intention-to-treat analysis. Seven, three and five women in the TwHF, MTX and combination groups, respectively, developed irregular menstruation (TwHF vs MTX monotherapy, p=0.216).
CONCLUSIONS:TwHF monotherapy was not inferior to, and MTX+TwHF was better than, MTX monotherapy in controlling disease activity in patients with active RA.
TRIAL REGISTRATION NUMBER:NCT01613079.
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PMID:
 
24733191
 
DOI:
 
10.1136/annrheumdis-2013-204807
[Indexed for MEDLINE]
  • Share on Facebook
  • Share on Twitter
  • Share on Google+
Publication types, MeSH terms, Substances, Secondar
Timothy Telymonde
​253 Main Street

Suite 355
Matawan, NJ 07747
+1-(740) 352-9594
Policies:​
Because we make every effort to ensure the quality of our products, all sales are final and we do not accept returns.

Deliveries are normally made within 3 business days. 

Under rare circumstances, products may be delivered within 30 working days.

*Disclaimer: 

All information discussed/printed herein and/or by our business affiliates do not constitute medical advice. We recommend that you consult your physician and/or health care professionals to determine if this product or products are right for you before consumption, especially if you are taking medications for any medical conditions, and to avoid any possible side effects. These statements have not been evaluated by the Food and Drug Administration. Further, this product is not intended to diagnose, treat, cure or prevent any disease. Expressly, all information supplied within our website or related public domains or during verbal discussion with any owner, owners, affiliates, or users’ testimonials have no warranty whatsoever. Since our product has not been tested in peer-reviewed double-blind controlled studies, all testimonials associated with this product should not provide assurance that you will have a similar outcome and/or similar side effects. You should clearly understand the above statements and fully accept total responsibility for what you do with the information and the resulting outcomes from your actions.  

If you are pregnant, lactating or are planning a pregnancy do not use this product. While on this product you may temporarily have a lower sperm count. Do not use if seal is broken. Keep out of reach of children, For adults only . store in a cool dry place.


 ​
  • Home
  • Flawless Defense Plus
  • Tripterygium Wilfordii Thunder God Vine
  • contact us
  • side effects
  • Testing
  • Affiliated sites
  • Tree of life